Interactive robots with model-based ‘autism-like’ behaviors

Translational control and autism-like behaviors

AUTISM SPECTRUM DISORDERS (ASD) CONSIST OF A SPECTRUM OF NEURODEVELOPMENTAL DISEASES WITH THREE SALIENT FEATURES: reduced social interactions, impaired communication and repetitive/stereotyped behaviors. In a recent study we found that increased eIF4E (eukaryotic initiation factor 4E)-dependent protein synthesis as a result of genetic deletion of Eif4ebp2 (eIF4E-binding protein 2) in mice, stim...

α5GABAA receptor deficiency causes autism‐like behaviors

The prevalence of autism spectrum disorders (ASDs), which affect over 1% of the population, has increased twofold in recent years. Reduced expression of GABAA receptors has been observed in postmortem brain tissue and neuroimaging of individuals with ASDs. We found that deletion of the gene for the α5 subunit of the GABAA receptor caused robust autism-like behaviors in mice, including reduced s...

CRISPR/Cas9-induced shank3b mutant zebrafish display autism-like behaviors

Background Human genetic and genomic studies have supported a strong causal role of SHANK3 deficiency in autism spectrum disorder (ASD). However, the molecular mechanism underlying SHANK3 deficiency resulting in ASD is not fully understood. Recently, the zebrafish has become an attractive organism to model ASD because of its high efficiency of genetic manipulation and robust behavioral phenotyp...

'Autistic Robots' for Embodied Emulation of Behaviors Typically Seen in Children with Different Autism Severities

The goal of this work is to enable interactions of humans with a humanoid robot that can be customized to exhibit behaviors typically observed in children with Autism Spectrum Disorders (ASD) along different severities. In a first step, we design robot behaviors as responses to three different stimulus families, inspired by activities used in the context of ASD diagnosis, based on the Autism Di...

Emotion-based Architecture for Social Interactive Robots